Rethinking the origins of inflammatory diseases | Wall Street Journal
October 6, 2022
By Shilpa Ravella
There is a yin and yang to inflammation that is analogous to using a fire hose. Too little water pressure in the hose and the fire—be it a germ or another intruder—wins. Too much and the body can turn on itself, drowning in autoimmunity. But sometimes the hose simply leaks, and a low-level inflammation simmers quietly in the body. We cannot see hidden inflammation with our naked eye—as we can the swollen joints of patients with rheumatoid arthritis and the rashes of those with lupus—or with the tools we typically use to diagnose inflammatory diseases. Otherwise healthy people walking around with this type of inflammation are entirely unaware that it exists within them. There may be no obvious signs or symptoms.